Thèse d'Alberto Terzolo

le 27 janvier 2022
Micro-mechanical modeling of human vocal folds : from quasi-static to vibratory loadings
Composed of collagen, elastin and muscular fibrous networks, human vocal folds are soft larygeal multilayered tissues owning remarkable vibro-mechanical performances. However, the impact of these tissues’ histological specifications on their overall mechanical properties remains elusive. Thereby, this work proposes a micro-mechanical model able to describe the 3D fibrous architecture and the surrounding matrices of the vocal-fold sublayers, and to predict their multiscale behavior accordingly. For each layer, the model parameters were identified using available histo-mechanical data, including their quasi-static response to physiological loading conditions (ie, tension, compression and shear). The evolution of microscopic descriptors such as fiber kinematics, deformation and interactions was simulated. Regardless of the loading mode, it was shown how macroscale nonlinear, viscoelastic and anisotropic tissue responses are inherited from fiber scale phenomena. Original scenarios of micro-mechanisms were also predicted for a large variety of loading conditions at various rates : (i) low-frequency cyclic and multiaxial loadings upon finite strains ; (ii) high-frequency small (SAOS) and large (LAOS) deformation oscillatory shear. In particular, the major role of 3D fiber orientation in tension, steric hindrance in compression, and the matrix contribution in shear was highlighted. Finally, the micromechanical model was implemented in a finite element (FE) code, yielding to a prior 3D simulation of vocal fold transient dynamics with relevant histo-mechanical properties. This work paves the way toward future multiscale simulations of vocal fold vibrations, accounting for various 3D fibrous healthy and pathological architectures.


Mme Aline BEL-BRUNON, Maître de Conférences, Institut National des Sciences Appliquées de Lyon (Examinatrice)
Mme Pascale ROYER, Directrice de Recherche, CNRS (Examinatrice)

M. Grégory CHAGNON, Professeur, Université Grenoble Alpes (Examinateur)
M. Stéphane LEJEUNES, Ingénieur de Recherche, CNRS (Rapporteur)
M. Yannick TILLIER, Professeur, École Nationale Supérieure des Mines de Paris (Rapporteur)
Mme Lucie BAILLY, Chargée de Recherche, CNRS (Directrice de thèse)
M. Laurent ORGÉAS, Directeur de Recherche, CNRS (Co-directeur de thèse)


  • Amphithéâtre André Rassat (Saint Martin d'Hères)
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Mis à jour le 26 janvier 2022